THE INTAKE OF PROCOMBO DURING TREATMENT WITH ANTIBIOTICS HAS SEVERAL POSITIVE EFFECTS ON HEALTH:

PROCOMBO RECOVERS THE BALANCE BETWEEN “GOOD” AND “BAD” BACTERIA
ProCombo does not let “bad” bacteria in intestine reproduce at the expense of “good” bacteria”. That balance guarantees good digestion and complete nutrient absorption in the human body. The result is quicker health recovery.

PROCOMBO REDUCES THE RISK OF DIARRHEA
The intake of ProCombo reduces the risk of acute diarrhea caused by antibiotics. The large quantity of live lactic acid bacteria Lactobacillus acidophilus in ProCombo maintains intestinal comfort during and after treatment. The lactic acid bacteria Lactobacillus acidophilus in ProCombo belongs to the so called “good bacteria”, which are natural inhabitants of human intestine and contribute to normal peristalsis.

THE BACTERIA IN PROCOMBO ARE RESISTANT TO ANTIBIOTICS
ProCombo contains live probiotic bacteria which are resistant to the negative effects of the commonly prescribed antibiotics. ProCombo should be taken along with antibiotic in order to prevent their negative effects on the human body – particularly on immunity and intestinal health.

HELPS STOMACH TO FUNCTION WELL

SHORTENS DURATION OF DIARRHEA
Due to the large quantity of live probiotic bacteria, ProCombo ensures quick recovery of the balance between “good” and “bad” bacteria.

REDUCES HEAVINESS AND DISCOMFORT IN STOMACH
Probiotic bacteria in ProCombo suppress the development of “bad” bacteria and lower the levels of toxic substances formed by them.

CONTRIBUTES TO REGULAR BOWEL MOVEMENT
ProCombo contributes to regular bowel movement in cases of constipation and digestive disorders, as lactic acid bacteria Lactobacillus acidophilus in it support normal gastrointestinal mobility and function.

REDUCES HEAVINESS IN STOMACH
Intake of ProCombo has a significantly positive impact on digestion. It helps to avoid stomach discomfort and the unpleasant feeling of heaviness in stomach.

IMPROVES DIGESTION IN CASES OF TRAVEL, UNHEALTHY DIET AND STRESS
ProCombo helps stomach and intestine to function normally under abnormal conditions – climate change, long trips, etc.

THE TECHNOLOGY OF QUICK RECOVERY

LIVE PROBIOTIC CULTURES
The state-of-the-art DUOCAPTM technology (capsule in capsule) keeps probiotic cultures viable

QUICKER RECOVERY
ProCombo in DUOCAPTM features a two stage release of probiotic bacteria directly in intestines, where their action begins

IDEAL DAILY DOSAGE
1 capsule daily gives you the ideal quantity of probiotic in the right place

PROCOMBO CONTAINS LIVE PROBIOTIC CULTURES
The DUOCAPTM technology, used for the production of ProCombo, is the only technology that keeps probiotic cultures live from the moment of their insertion in a capsule up until the dissolving in the human gastrointestinal tract. Upon sealing of DUOCAPTM capsules, probiotic bacteria are not chemically or thermally treated. Controlled release ensures additional protection of probiotic bacteria against stomach acids. All that guarantees the extremely high percentage of viable probiotic bacteria in each and every capsule of ProCombo.

PROCOMBO ENSURES QUICKER RECOVERY
DUOCAPTM (capsule in capsule) ensures quick and long lasting improvement of intestinal balance. With its help, the ingredients of ProCombo are released in two stages – the first stage is in stomach, the second – in the small intestine.

First stage of dissolution: Outer capsule is dissolved and prebiotic is released. Prebiotic is the nutriment needed for the probiotic bacteria to survive and develop.

Second stage of dissolution: Inner capsule is dissolved and probiotic is released. Probiotic bacteria are viable, have enough nutrients (prebiotic substance) and are delivered directly in their “home” – the intestine.

1 CAPSULE OF PROCOMBO GIVES YOU ALL “GOOD” BACTERIA YOU NEED DAILY
Due to the DUOCAPTM technology, one capsule of ProCombo contains the whole quantity of probiotic cultures an adult needs for a day. That makes ProCombo suitable for daily intake and much more effective.

QUESTIONS AND ANSWERS

COULD PROCOMBO BE TAKEN BY PEOPLE SUFFERING FROM GASTROINTESTINAL DISORDERS?
The ProCombo symbiotic could be taken safely by people with different health conditions: reducing the risk or relieving the symptoms of an allergy; radiation-induced diarrhea; inflammatory bowel diseases (Crohn's disease and ulcerative colitis); irritable bowel syndrome; colonic diverticulosis; uro-genital infections; for prevention of postoperative infections after abdominal surgery.

ARE THERE ANY MEDICAL CONDITIONS IN CASE OF WHICH INTAKE OF PROCOMBO ARE NOT RECOMMENDED?
ProCombo could be taken safely for a long period of time, as it contains a live culture - Lactobacillus acidophilus. The product is not recommended for critically ill patients in intensive care or patients with serious immune system disorders – due to the theoretical risk of infections.

WHAT IS THE RECOMMENDED INTAKE PERIOD OF PROCOMBO?
There are no exact recommendations for the duration of the treatment with probiotics. It depends on different factors, most important of which are the type of probiotic and its ingredients, the degree of distortion in the intestinal microflora, and the clinical condition for which the probiotic is prescribed. The duration of the treatment should be determined by the treating physician, the recommended intake period is between 2 and 8 weeks.

WHAT EFFECTS COULD BE EXPECTED AFTER A 10-DAY INTAKE OF PROCOMBO?
Depending on the underlying disease that has led to dysbiosis, improvement of the intestinal microflora and digestion, as well as reduction of the related to the dysbiosis problems - abdominal discomfort, flatulence (gas) and others could be expected after intake of ProCombo.

WHY IS PROCOMBO TAKEN DURING THE ANTIBIOTIC TREATMENT?
Usually, antibiotic treatment distorts the composition and metabolic activity of the normal intestinal flora. That side effect occurs during the first three days of the intake of antibiotics. Antibiotics-induced dysbiosis has adverse effects on human health, some of which remain long after the end of the antibiotic treatment. The use of ProCombo is among the promising strategies for reducing the negative effects of treatment with antibiotics.

AT WHAT POINT OF THE ANTIBIOTIC TREATMENT SHOULD THE INTAKE OF PROCOMBO BEGIN?
Probiotics could be taken during the antibiotic treatment or after it. The best option is the intake of ProCombo to start along with the intake of antibiotics.

HOW SHOULD PROCOMBO BE TAKEN, GIVEN THE ANTIBIOTIC TREATMENT SCHEME?
When taken along with antibiotics, ProCombo should be taken at least 2 hours before or after the antibiotic.

CAN A PERSON OVERDOSE WITH PROCOMBO?
The risk of overdose with ProCombo is insignificantly low. If a person takes more than the recommended dose, that could cause abdominal discomfort and gas flatulence), which are relieved shortly afterwards.

COULD PROCOMBO BE TAKEN BY CHILDREN?
There are no known reasons why ProCombo could not be taken by children and adolescents. ProCombo could be taken by children over 4 years old – age is determined by the ability of the child to safely swallow the capsule.

COULD PROCOMBO BE TAKEN BY PREGNANT AND NURSING WOMEN?
The product could be safely taken by women during pregnancy and/or nursing.

GOOD TO KNOW

PROBIOTICS IN HUMAN BODY WEIGH MORE THAN A HUMAN BRAIN
A normal human brain weighs around 1.1 kg, while in a healthy human body there are 1.3 kg of probiotic bacteria and other microorganisms. A human heart weighs only 0.3 kg, a human lever – around 1.5 kg, which makes probiotic bacteria one of the largest organs in the human body.

IN HUMAN BODY, THERE ARE 10 TIMES MORE PROBIOTIC BACTERIA THAN CELLS
A healthy human body contains more than 100-300 trillion probiotic bacteria, compared to just 10 trillion cells. Some scientists say that if probiotic bacteria from just one man are put next to each other, their length will be equal to 2.5 times the circumference of the Earth.

PROBIOTIC BACTERIA INHABIT THE WHOLE HUMAN BODY (NOT ONLY THE STOMACH)
Most of the probiotic bacteria in humans inhabit the large intestine. However, billions of them are to be found in the mouth, oral cavity, nasal cavity, esophagus, gums and the pleural cavity (around the lungs). Probiotic bacteria also live in the stomach, small intestine, vagina, around the rectum, in joints, armpits, under toe nails, between toes, in urinary tract and urinary passages, as well as in many other locations in the human body!

400 PROBIOTIC STRAINS INHABIT THE HUMAN BODY
According to a number of scientific studies, over 400 strains of probiotic bacteria inhabit the human body. Some of them are constant inhabitants, while others are temporarily present in it. Actually, 75% of the whole volume of probiotic bacteria, which inhabit the human body, is formed of only 20 strains. The best known and thoroughly studied strain with proven medical benefits is Lactobacillus acidophilus. Because of that fact, it is part of ProCombo.

PROBIOTICS ARE RESPONSIBLE FOR 70% OF THE IMMUNE RESPONSE
According to Casey Adams Ph.D., probiotic play a vital role in 70–80% of the immune response of the human body against pathogenic invaders. Probiotics stimulate all immune cells – from T-killers to macrophages. Probiotics also stimulate cytokines and phagocytic cells in order to be able to control the immune response in accordance with the needs in different situations.

PROBIOTICS FIGHT COLDS AND CONSTIPATION
It will hardly be a surprise for you that probiotics could relieve constipation. However, you definitely will be surprised by the fact that probiotics have a major role in fighting colds.
It really sounds amazing, but it is a proven fact that numerous probiotics have shown that they help in fighting viruses such as colds, influenza, rotavirus, herpes and ulcers. In New Delhi, 100 children (age 2 to 5 years) were given Lactobacillus acidophilus for 6 months. Those children were proven to suffer less from colds, flu, diarrhea and fever compared to the group that had been taking placebo (in results from: Saran et al. 2002).

PROBIOTICS HELP US GET VITAMINS
Probiotics are proven to participate in the production of a large part of the vitamins in the human body, such as:

Vitamin ?;
Vitamin ?;
Vitamins ?1–?3, ?5–?7, ?9, ?12;
Essential fatty acids.

In addition to that, probiotics also improve digestibility, bioavailability, and processing of a large number of beneficial substances, some of which are:

Copper, Calcium ,Magnesium, Iron, Manganese, Potassium, Zinc, Proteins, Fats, Carbohydrates, Sugars, Milk, Phytonutrients, Cholesterol

The two lists are compiled and published by Casey Adams, Ph.D. in his book „Probiotics – Protection Against Infection”.

WHAT IS THE DIFFERENCE BETWEEN PROBIOTIC AND PREBIOTIC?
Prebiotics are nutritional fibers – „food” for the so called good bacteria in gastrointestinal tract. Modern people’s diet, however, is poor in prebiotic fibers. As a result, the amount of „good” bacteria decreases, which leads to constipation, diarrhea, bloating, gas...
Probiotics are the live microorganisms themselves – bacteria that inhabit the gastrointestinal tract and ensure the healthy balance of the intestinal flora. They participate not only in the digestive processed in the human body, bit also in any other processes that are crucial for the good health.

Therefore, ProCombo contains an ideal combination of beneficial bacteria (probiotic) and their nutrition (prebiotic), which ensures quicker recovery of the normal gastrointestinal activity.

PROBIOTICS IMPROVE VAGINAL HEALTH
It is well known that in female vagina there is a colony of probiotic bacteria that repel „invaders”. Oral intake of probiotics could contribute to the effective prevention and treatment of vaginitis and vaginosis. Probiotics that contain Lactobacillus acidophilus, such as ProCombo, could contribute to the removal of unpleasant odors from the intimate area, as well as to the normalization of pH to 4.5.

Good vaginal flora of pregnant women is the first warranty for the good health of the infant. Few people are aware of the proven fact that during the normal (vaginal) birth, the baby receives its first portion of probiotic bacteria from the mother’s vagina. 60% of the babies born vaginally receive their first portion of probiotic bacteria Bifidus Infantis, compared to only 1% of the babies born by C-section. After the first portion of probiotic bacteria, received during the normal (vaginal) birth, the newborn baby gets the remaining quantity of necessary probiotic from the breast milk. More than 40% of the ingredients of the breast milk are probiotic substances.

All those facts prove how beneficial for the good health of the infant the intake of a probiotic such as ProCombo is – before, during and after birth.

4 RULES WHEN CHOOSING A WORKING PROBIOTIC PRODUCT IT SHOULD CONTAIN LIVE PROBIOTIC BACTERIA
Only viable bacteria could have positive effect on gastrointestinal health.

IT SHOULD CONTAIN NO LESS THAN 10 BILLION VIABLE BACTERIA
Such quantity ensures quicker recovery and a possibility for the “good” bacteria to remain the human body longer after intake is terminated.

IT SHOULD CONTAIN PREBIOTIC
Prebiotic is the nutrition needed for the growth and activity of probiotic bacteria. Thanks to prebiotic, probiotic bacteria obtain the necessary environment, and could develop and act the way they are supposed to.

IT SHOULD NOT CONTAIN SWEETENERS AND FLAVORS
Those substances could become part of metabolism and/or the structures of the “bad” bacteria. As a result, those dangerous bacteria could become even more aggressive.
ProCombo is based on those four important requirements – the product fulfills all of them.

IMPORTANT: If you take a probiotic product in order to treat a problem that you have, it is very important to reduce the intake of sugar. It is considered that sugar provides an environment that is beneficial for the development of disease entities (cells, substances, etc.). Sugar is also believed to hinder the action of probiotics in their full capacity.

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PROCOMBO
SYNBIOTIC – FOR INTESTINAL MICROFLORA BALANCE
dietary supplement
2 blister packs x 5 capsules • 708 mg

200 bln CFU/g Lactobacillus acidophilus

INDICATIONS: ProCombo ensures effective maintenance of the balance of the nor-mal intestinal microflora. It produces a sufficient amount of live probiotic cultures (Lactobacillus acidophilus La-14® (200 bln CFU/g) as well as prebiotic fructooligosac-charides needed for their growth and development in the human gastrointestinal tract. It is highly effective and supports the maintenance of the functions of the gastrointestinal tract and the proportion of the beneficial microorganisms in it.

ProCombo provides good results in the following aspects:

REGULATION OF INTESTINAL MOTILITY: Probiotics support the function of the intestine by creating favorable conditions for normal defecation.

HEALTHY DIGESTION: ProCombo ensures effective processing of the food (diges-tion), absorption of nutrients from it, and regular disposal of the residual waste after food is processed.

RECOVERY OF THE FUNCTIONS OF THE GASTROINTESTINAL TRACT AFTER INTAKE OF ANTIBIOTICS: It supports the recovery of the population of beneficial bacteria in the gastrointestinal tract, and the reduction of the side effects after intake of antibiotics.

REGULATION OF THE MICROBIAL BALANCE IN THE GASTROINTESTINAL TRACT: ProCombo supports the good health and reduces the adverse effects on the human body caused by unhealthy lifestyle, stress, etc.

ACTION: ProCombo is a synbiotic – a synergic combination of probiotic cultures Lac-tobacillus acidophilus and prebiotic short-chain fructooligosaccharides. L. acidophilus is one of the most beneficial microorganisms (probiotic). It creates conditions for development of a normal intestinal flora. L. acidophilus adheres to the epithelial cells of the intestinal mucosa. As soon as the probiotics colonize it, they create a close contact with the intestinal immune system (70% of the human immune system is concentrated in the gastrointestinal tract), thus supporting the immune response. Intake of L. acidophilus is beneficial in case of disturbances of the gastrointestinal function, after intake of drugs and antibiotics, after dieting, for elderly people with disturbed absorption of lactose in milk (lactose intolerance), etc.

Short-chain fructooligosaccharides (prebiotic) are low-calorie, non-digestible carbo-hydrates that promote the normal growth and activity of the beneficial intestinal microflora. They pass through the stomach and small intestine, and reach the large intestine without being digested or absorbed. After reaching their destination, they selectively nourish only beneficial bacteria such as L. acidophilus. The prebiotic facili-tates the adhesion of probiotics to the intestinal mucosa and the reproduction of beneficial flora in the intestines.

Prebiotics ensure the vital activity of the probiotic microorganisms and help them survive in the acid environment of the stomach and small intestine, in which there are high concentrations of bile salts.

ENCAPSULATION TECHNOLOGY DUOCAP-TM
ProCombo is manufactured in France as per the patented DuoCapTM by Capsugel (capsule-in-capsule) technology for combination and dual release of ingredients.The technology allows liquids to be inserted in hard gelatin capsules without any thermal treatment of the active substance. That keeps the life of the probiotic cultures and guarantees that they reach the host (intestinal mucosa) successfully.

Gelatine capsules DuoCapTM are:
solvent free;
preservative free;
gluten free;
sugar free;
GMO free.

DUOCAP-TM DUAL RELEASE OF INGREDIENTS

ProCombo in DuoCapTM has a proven stable quantity of viable probiotic bacteria since the moment of sealing the capsule until the intake*. With DuoCapTM the active ingredients are protected against the acidic environment in the stomach.

RECOMMENDED DAILY DOSE: 1 capsule daily, 1–2 hours after a meal with a suf-ficient amount of liquids (at least one glass of water).

CONTENT of recommended daily dose of 1 capsule: Lactobacillus acidophilus, from milk (L. acidophillus La-14®, 200 bln CFU/g) – 75 mg; short-chain fructooligosaccha-rides (FOS 95 % short-chain NutraFlora®) – 65 mg.

Additional ingredients: humectant: glycerol; hydroxypropyl methyl cellulose; anti-caking agent: microcrystalline cellulose, silicon dioxide. Capsule: gelatin of plant ori-gin; colour: titanium dioxide.

CONTRAINDICATIONS: There are not known contraindications.

STORAGE CONDITIONS: Keep at room temperature (15°–25°?), do not expose to direct light. Keep out of the reach of children.

Do not exceed the recommended daily dose.
Do not use the product as substitute to the balanced diet.

CFU (Colony-forming unit) – a unit for viable probiotic cultures
which are able to form colonies.

PRODUCED BY:
CAPSUGEL – FRANCE