The series, a hybrid of House's medical detectives and Dawson's Creek's hormones and catchy pop-rock soundtrack, follows five competitive surgical interns at the fictional Seattle Grace Hospital. There's optimistic ex-model Izzie (Katherine Heigl), bumbling do-gooder George (T.R. Knight), competitive glacier Cristina (Sandra Oh), cocky womanizer Alex (Justin Chambers), and the show's namesake, Meredith Grey (Ellen Pompeo), whose medical career is complicated by her famous surgeon mother who now lives with Alzheimer's, and her frowned-upon relationship with another surgeon, Derek Shepherd (Patrick Dempsey, enjoying the best career revival since Rob Lowe). The doctors juggle romance and foster friendships while trying not to stab each other in the back over surgeries.

Grey's Anatomy's first season, while entertaining, went a little far trying to find its groove, overdosing on Meredith's overly simplistic voice-overs ("At the end of the day faith is a funny thing"), and musical montages. It has the usual trappings of a hospital drama (unusual cases, such as the patient with the 70-pound tumor, and trysts in the on-call room), but with more warm fuzzies and light touches. (Sometimes, a little too light--the opening credits sequence features an eyelash curler next to medical instruments and red-painted toes savorting with a male patient under a sheet)

Pompeo, who can sound just like Renee Zellweger if you close your eyes, is likeable but not strong enough of a presence compared to her co-stars. Luckily the quirky dialogue and stellar acting by the ethnically diverse cast, particularly by Chandra Wilson (Dr. Bailey, aka "the Nazi") and Oh, who won a Golden Globe for best supporting actress, more than make up for it. The DVD covers the first season's nine episodes, plus commentary on the pilot and a behind-the-scenes feature. --Ellen A. Kim